<p>The presence of polyols or sugars (dark grey circles) induces compactization of CA structure and inhibits the formation of high-order CA structures. In contrast, the presence of the methylamines TMAO, betaine or sarcosine (light grey circles) destabilizes CA structure and thus promoting CA-CA interactions, resulting in the formation of CA cylinders. Structure of HIV-1 CA (151–231) created using PDB 1A8O <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0060867#pone.0060867-Gamble1" target="_blank">[52]</a> represents full-length CA protein. The scale bars are 100 nm (left image) and 200 nm (right image).</p
<p>(<b>A</b>) Crystal structure of the HIV-1 CA<sup>N</sup>:CPSF6<sub>313–327</sub> complex. HIV-1 C...
AbstractBased on structural information, we have analyzed the mechanism of mature HIV-1 core assembl...
The CA (capsid) domain of immature HIV-1 Gag and the adjacent spacer peptide 1 (SP1) play a key role...
<p><i>In vitro</i> CA assembly assay was performed in 50 mM Na<sub>2</sub>HPO<sub>4</sub> buffer (pH...
SummaryThe capsids of mature retroviruses perform the essential function of organizing the viral gen...
AbstractThe protein CA forms the mature capsid of human immunodeficiency virus. Hexamerization of th...
Chemical chaperones are small organic molecules which accumulate in a broad range of organisms in va...
The folding of HIV-1 protease to its active form involves the coordination of structure formation an...
The mature capsids of human immunodeficiency virus type 1 (HIV-1) and other retroviruses are fullere...
International audienceCapsid protein (CA) is the major component of the human immunodeficiency virus...
AbstractCoarse-grained models of the HIV-1 CA dimer are constructed based on all-atom molecular dyna...
SummaryThe mature capsids of HIV and other retroviruses organize and package the viral genome and it...
<p>(A) The initial conformation of the hexameric ring with NTD sitting on the outer wall of tube. Ea...
<p>Location of CA mutations that are solvent-exposed in the hexameric CA structure and which are fou...
dissertationThe human immunodeficiency virus type 1 (HIV-1) initially assembles as a spherical, imma...
<p>(<b>A</b>) Crystal structure of the HIV-1 CA<sup>N</sup>:CPSF6<sub>313–327</sub> complex. HIV-1 C...
AbstractBased on structural information, we have analyzed the mechanism of mature HIV-1 core assembl...
The CA (capsid) domain of immature HIV-1 Gag and the adjacent spacer peptide 1 (SP1) play a key role...
<p><i>In vitro</i> CA assembly assay was performed in 50 mM Na<sub>2</sub>HPO<sub>4</sub> buffer (pH...
SummaryThe capsids of mature retroviruses perform the essential function of organizing the viral gen...
AbstractThe protein CA forms the mature capsid of human immunodeficiency virus. Hexamerization of th...
Chemical chaperones are small organic molecules which accumulate in a broad range of organisms in va...
The folding of HIV-1 protease to its active form involves the coordination of structure formation an...
The mature capsids of human immunodeficiency virus type 1 (HIV-1) and other retroviruses are fullere...
International audienceCapsid protein (CA) is the major component of the human immunodeficiency virus...
AbstractCoarse-grained models of the HIV-1 CA dimer are constructed based on all-atom molecular dyna...
SummaryThe mature capsids of HIV and other retroviruses organize and package the viral genome and it...
<p>(A) The initial conformation of the hexameric ring with NTD sitting on the outer wall of tube. Ea...
<p>Location of CA mutations that are solvent-exposed in the hexameric CA structure and which are fou...
dissertationThe human immunodeficiency virus type 1 (HIV-1) initially assembles as a spherical, imma...
<p>(<b>A</b>) Crystal structure of the HIV-1 CA<sup>N</sup>:CPSF6<sub>313–327</sub> complex. HIV-1 C...
AbstractBased on structural information, we have analyzed the mechanism of mature HIV-1 core assembl...
The CA (capsid) domain of immature HIV-1 Gag and the adjacent spacer peptide 1 (SP1) play a key role...