Effect of TTX on LDCs.

<p>Spatiotemporal maps created from video recordings of motor patterns of the whole rat colon. All arrows indicate infusion of PBS into proximal colon. a. Control LDCs followed by addition of TTX, added 1 min before the start of panel b. b. TTX abolished induced and rhythmic LDCs. Fluid infusion occurred at arrows. Rhythmic contractions remained in the proximal colon and a few propagated into the mid colon. c. Control LDCs (different animal). d. TTX was added 7 min before the start of panel d. TTX abolished induced and rhythmic LDCs. Rhythmic motor activity remained in the proximal colon. e. Carbachol, 2×10⁻⁶ M, was added 10 min before start of panel e. Carbachol, in the presence of TTX induced rhythmic LDC-like activity as well as retrograde contractions in the distal colon.