Lidocaine and bethanechol.

<p>Spatiotemporal maps created from video recordings of motor patterns of the whole rat colon. All arrows indicate infusion of PBS into proximal colon. a. Control LDCs with distal RPMCs. b. Lidocaine abolished LDCs but rhythmic contractile activity remained up to 6/min. Two retrograde contractions were seen. Lidocaine was added 3 min before start of panel b. c. Addition of bethanechol (2×10⁻⁶ M) introduced LDC-like activity as well as retrograde contractions in the distal colon. Fluid infusion effects were variable, sometimes without effect (first arrow), sometimes inducing a propulsive contraction. Bethanechol was added 14 min before start of panel c.