Lesion-directed microglial process movement is impaired in a mouse model of cerebral amyloidosis.

<p>(<b>A</b>) Representative intravital two-photon microscopy images and (<b>B</b>) time course of microglial process movement towards a laser-induced micro-lesion (dashed circle) in 8 month old live anaesthetized <i>APPPS1</i>-<i>Cx3cr1</i>^+/gfp (n = 6) and <i>Cx3cr1</i>^+/gfp mice (n = 8). Aβ plaques are stained with Methoxy-XO4 (blue, *). (<b>C</b>) Representative images and (<b>D</b>) relative microglial response to laser lesions in acute cortical cerebral slices of 10 month old <i>APPPS1</i>-<i>Cx3cr1</i>^+/gfp (n = 8) and <i>Cx3cr1</i>^+/gfp (n = 7) mice. Aβ plaques are stained with Thiazine Red (red, *). Data are mean ± s.e.m, *p<0.05. Scale bars: 10 µm. a.u. = arbitrary units.