<p>The levels of peptides derived from intracellular proteins were studied using quantitative peptidomics. The relative levels of peptides in WT mice (black circles) and <i>pcd</i> mice (grey circles) are indicated for (<b>A</b>) amygdala of adult mice; (<b>B</b>) amygdala of 3-week old mice; and (<b>C</b>) cerebellum of 3-week old mice. Each dot in the graph shows the ratio between a peptide in one WT or <i>pcd</i> replicate versus the average level in the WT replicates. The x-axis reflects the number of peptides found in <i>pcd</i> mice. See <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0060981#pone.0060981.s003" target="_blank">Table S1</a> for data.</p
<p>(A) Young mice (4 weeks old) and (B) wild-type old mice (84 weeks old). The green stars represent...
Brains were collected from subset groups, and histological changes were determined as described in t...
P>Neuropeptides are produced from larger precursors by limited proteolysis, first by endopeptidases ...
<p>For this analysis, the intracellular peptides listed in <a href="http://www.plosone.org/article/i...
<p>Data from the analysis of peptides in whole brain (minus the cerebellum and olfactory bulb) from ...
<p>Representative spectra show the 2+ ions for the D0 to D12-TMAB peaks of the peptide subsequently ...
<p>Peptides derived from intracellular proteins that were commonly detected in young and adult mouse...
Cytosolic carboxypeptidase 1 (CCP1) is a metallopeptidase that removes C-terminal and side-chain glu...
<p>Peptides derived from secretory pathway proteins that were commonly detected in the hypothalamus ...
<div><p>Cytosolic carboxypeptidase 1 (CCP1) is a metallopeptidase that removes C-terminal and side-c...
Cells produce and use peptides in distinctive ways. in the present report, using isotope labeling pl...
<p>Secretory pathway peptides detected in <i>pcd</i> mouse amygdala and hypothalamus were divided in...
Brain derived peptides function as signaling molecules in the brain and regulate various physiologic...
Peptides have been proposed to function in intracellular signaling within the cytosol. Although cyto...
<p>(<b>A</b>) Phosphorylated peptides identified in hippocampal fractions of aged (yellow; n = 9) an...
<p>(A) Young mice (4 weeks old) and (B) wild-type old mice (84 weeks old). The green stars represent...
Brains were collected from subset groups, and histological changes were determined as described in t...
P>Neuropeptides are produced from larger precursors by limited proteolysis, first by endopeptidases ...
<p>For this analysis, the intracellular peptides listed in <a href="http://www.plosone.org/article/i...
<p>Data from the analysis of peptides in whole brain (minus the cerebellum and olfactory bulb) from ...
<p>Representative spectra show the 2+ ions for the D0 to D12-TMAB peaks of the peptide subsequently ...
<p>Peptides derived from intracellular proteins that were commonly detected in young and adult mouse...
Cytosolic carboxypeptidase 1 (CCP1) is a metallopeptidase that removes C-terminal and side-chain glu...
<p>Peptides derived from secretory pathway proteins that were commonly detected in the hypothalamus ...
<div><p>Cytosolic carboxypeptidase 1 (CCP1) is a metallopeptidase that removes C-terminal and side-c...
Cells produce and use peptides in distinctive ways. in the present report, using isotope labeling pl...
<p>Secretory pathway peptides detected in <i>pcd</i> mouse amygdala and hypothalamus were divided in...
Brain derived peptides function as signaling molecules in the brain and regulate various physiologic...
Peptides have been proposed to function in intracellular signaling within the cytosol. Although cyto...
<p>(<b>A</b>) Phosphorylated peptides identified in hippocampal fractions of aged (yellow; n = 9) an...
<p>(A) Young mice (4 weeks old) and (B) wild-type old mice (84 weeks old). The green stars represent...
Brains were collected from subset groups, and histological changes were determined as described in t...
P>Neuropeptides are produced from larger precursors by limited proteolysis, first by endopeptidases ...