Heat map representation of relative levels of secretory pathway peptides in adult <i>pcd</i> and other mutant mouse brains.

<p>Peptides derived from secretory pathway proteins that were commonly detected in the hypothalamus of cilia mutants, <i>pcd</i>, WT, <i>Cpe^fat/fat,</i> and prohormone convertase 2 knockout mice were included in this analysis. Each row represents a different peptide. The color shows the ratio between a peptide in one WT or mutant mouse replicate versus the average level in WT mice within each LC/MS run. The color scheme is identical to that used in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0060981#pone-0060981-g008" target="_blank">Figure 8</a>. Additional abbreviations: sd, standard deviation; n, number of replicates; sig, statistical significance of difference with the WT/WT value (calculated using Student’s t-test); *, p<0.05; **, p<0.01; ns, not significant; fat/WT, the ratio of peptides in <i>Cpe^fat/fat</i> mice relative to WT mice; PC2KO/WT, the ratio of peptides in prohormone convertase 2 knock-out mice relative to WT mice. See <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0060981#pone.0060981.s003" target="_blank">Table S1</a> for data.