MPP⁺-induced MPO levels and ROS were reduced by resveratrol in microglia.

<p><b>A.</b> BV2 microglia were treated with 0.1 µM 1-methyl-4-ph9enylpyridinium (MPP⁺) and/or 5 µM resveratrol (RESV) for 1 day, after which the intracellular levels of MPO were analyzed by FACS using an anti-MPO antibody. *<i>P = 0.002,</i> **<i>P = 0.014</i> when compared with MPP⁺-treated cell. <b>B.</b> BV2 microglia were treated with 01 µM MPP⁺ and/or 5 µM resveratrol for 3 h, and then incubated with 5 µM DCF for 30 min at 37°C. DCF fluorescence was measured by FACS analyses. The data are representative of three independent experiments with similar results. The graph represents the fold changes in MFI (mean fluorescence intensity) ± SD from three independent experiments in triplicate. *<i>P = 0.006,</i> **<i>P = 0.018</i> when compared with MPP⁺-treated cell.