Multivariate Analysis of Survival for the Cohorts with High and Low CcO Activity.

<p><b>Panel A</b> shows the Kaplan-Meier estimate of the probability of overall survival, according to CcO activity, in all 84 patients combined from the training and validation tissue cohorts (P<0.0001 by the log-rank test; hazard ratio for death in patients with high CcO activity, 24.20; 95% CI, 9.12 to 34.20). Red denotes tumors with low CcO activity and blue denotes tumors with high CcO activity. <b>Panel B, C, D, and E</b> show the probability of survival in patients with high (left) and low (right) CcO activity with respect to age (Panel B; hazard ratio, 0.24; P = 0.14), gender (Panel C; hazard ratio, 0.58; P = 0.42), treatment administered (Panel D; hazard ratio, 0.39; P = 0.05) and MGMT promoter methylation status (Panel E; hazard ratio, 0.9; P = 0.83). Black circles denote censored points, and the numbers between brackets indicate the median survival for each group. CcO denotes cytochrome c oxidase, F denotes female, M denotes male, TMZ denotes temozolomide, and Rad denotes radiotherapy.