Group (RR-MS, HC) by BDNF genotype (Val⁶⁶, Met⁶⁶) interaction.

<p>Left and right parahippocampal place areas (<b>A–B</b>), left posterior hippocampus (<b>C</b>), and left posterior cingulate cortex (PCC) (<b>D</b>) showed greater response in RR-MS Val⁶⁶ homozygous versus RR-MS Met⁶⁶ carriers while the <i>opposite was true</i> for HC (i.e., greater response in HC Met⁶⁶ carriers versus HC Val⁶⁶ homozygous). Color bars represent F statistics. Coordinates (X, Y, Z) are in the Montreal Neurological Institute space. Only for a display purpose, maps are thresholded at P<0.001, uncorrected, but results are significant at P<0.05, Family-Wise Error (FWE), whole-brain correction (<b>A–B</b>) and small volume correction (svc) (<b>C–D</b>). BOLD = blood oxygenated level dependent; R = right hemisphere; RR-MS = Relapsing-Remitting Multiple Sclerosis; HC = Healthy Controls.