The pharmaceutical FX alters cell signaling endpoints and <i>ABCB</i> mRNA expression in mussel haemocytes under <i>in vivo</i> exposures.

<p>(A) cAMP content (B) relative PKA activities (C) relative <i>ABCB</i> mRNA expression. All biological endpoints were assessed in haemocytes collected from mussels exposed for 7 days to 0.3 ng/L FX 0.3 ng/L PROP, or to the mixture FX+PROP (0.3 ng/L+0.3 ng/L). A group of control (water) exposed mussels were included in the analysis. Data represent mean ± SEM (N = 5). Different superscripts letters indicate statistically significant differences (p<0.05, one-way ANOVA followed by Bonferroni's test). Basal PKA activity = 0.88±0.07 nmol/min/mg protein.