Adult social approach in B6, BTBR, and F2 mice.

<p>(A) B6 exhibited high sociability, spending significantly more time in the chamber containing the novel mouse than in the chamber containing the novel object, and (C) more time sniffing the novel mouse than the novel object. BTBR exhibited low sociability and did not show preference for the novel mouse. (E) As compared to B6, BTBR mice exhibited significantly higher levels of self-grooming in an empty cage. In the present study, F2 mice exhibited broad ranges of time spent in the novel mouse chamber (B), time sniffing the novel mouse (D), and self-grooming in an empty cage (F). The parental strains and F2 generation were tested using identical methods, by the same NIMH investigators in the Bethesda laboratory. The F2 scores shown in panel B and panel D represent the time spent in the chamber with the novel mouse Panel A and the time spent sniffing the novel mouse and time spent sniffing the novel object in Panel C, respectively. (A, C)*p<.05 for the comparison between novel mouse and novel object; (E)*p<.01 vs. B6. A, C, E display Mean ± SEM; bold red line in B, D, F indicates mean value. <i>B6 and BTBR data from A, C, and are adapted from Yang et </i><i>al., 2009, European Journal of Neuroscience, Copyright (c) 2009, Blackwell Publishing, Ltd., with reuse and reprint permission via the Copyright Clearance Center (CCC).</i>