Positive and negative-like phenotypes.

<p><b>A.</b> In the novel open field test, no difference in horizontal activity between mutant (black triangle, n = 8) mice and Flox (while square, n = 14) controls (two-way repeated measures ANOVA; <i>p</i> = 0.56). <b>B.</b> No significant difference for genotype (black for mutant (n = 9), white for Flox (n = 9)) in amphetamine-induced locomotor response (two-way repeated measures ANOVA after treatment; <i>p</i> = 0.12). <b>C.</b> No difference between mutant (black, n = 10) and Flox (white, n = 12) mice in the social recognition task (two-way repeated measures ANOVA; <i>p</i> = 0.56). <b>D.</b> In the saccharine preference test, both genotypes consumed saccharine more and no difference between mutant (black, n = 11) and Flox (white, n = 12) mice in saccharine preference (two-way ANOVA/LSD <i>post-hoc</i> test; <i>p</i> = 0.74). <b>E.</b> Mutant mice (black bar, n = 8) performed similarly to Flox controls (while bar, n = 9) in the female urine sniffing test (two-way ANOVA/LSD <i>post-hoc</i> test; <i>p</i> = 0.59). <b>F.</b> Mutant mice (n = 12) were comparable to flox controls (n = 11) in time spent in the open arm of the elevated plus maze (two-tailed t-test; <i>p</i> = 0.73).