Renal endpoints for patients receiving sodium bicarbonate versus sodium chloride.

<p>Number of patients receiving sodium bicarbonate (black bars) developing acute kidney injury after open heart surgery compared to patients receiving sodium chloride (white bars). The OR (with 95% CI) shows the risk of developing a pre-defined renal endpoint of patients treated with sodium bicarbonate compared to those treated with sodium chloride. From left to right: primary endpoint: increase in plasma creatinine &gt;25% or &gt;0.5 mg/dl (&gt;44 µmol/l), secondary endpoints: increase in plasma creatinine &gt;50%, increase in plasma creatinine &gt;100%, RIFLE-classification based acute kidney injury (risk, injury, failure loss, and end stage renal failure criteria, <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001426#pmed.1001426-Bellomo2" target="_blank">[15]</a>) and acute renal replacement therapy (RRT) within index hospitalization.