Knockdown of AMIGO3 promotes DRGN neurite outgrowth in the presence of CME.

<p>(<b>A</b>) Representative photomicrographs of βIII-tubulin⁺ DRGN neurite outgrowth in untransfected and siRNA transfected DRG cells in the presence or absence of CME with or without FGF-2 ± SEM. Quantification of (<b>B</b>) mean number of DRGN with neurites ± SEM and (<b>C</b>) mean neurite length after treatment with AMIGO3 in the presence of CME, with and without FGF-2 ± SEM. *** = P<0.0001, ANOVA. Scale bar in (A) = 100 µm.