ROC curves for prediction of protein-protein interactions.

<p>We compare the performance of predicting protein-protein interactions using all available annotations from GOA (labeled “original” in the graphs) and using GOA’s annotations combined with our inferred functions (labeled “new” in the graphs). For the evaluation, we used 4,834 genetic interactions in yeast, 500 interactions in fly, 23 interactions in fish, 3,152 interactions in mouse and 765 interactions in worm. We also show the ROC curve resulting from the combined annotations and interactions in all five species. All ROC curves include the line of non-discrimination (labeled “x” in the graphs). The detailed evaluation results are provided as supplementary material.