YAP/TAZ is involved in fibrochondrogenesis of MSCs.

<p>A: MSCs were transfected with siYAP and siTAZ, and efficient knockdown of the endogenous proteins were analyzed by Western blot analysis. B–F: Fibrochondrogenesis-related gene expression of Sox9 (B), Runx2 (C), collagen I (D), collagen II (E), and aggrecan (F) was analyzed after 4 weeks of differentiation under perpendicular flow with a peak shear stress of 1 dyne/cm². Data were presented as mean ± SEM. *<i>p</i><0.01, siYAP/TAZ vs. sicontrol. ^†<i>p</i><0.05 perpendicular flow vs. static for sicontrol group. ^#<i>p</i><0.05, perpendicular flow vs. static for siYAP/TAZ group.