<p>Cysteine proteases and associated MEROPS clans sorted according to the number of known substrates in MEROPS n. Subpocket-wise cleavage entropies S<sub>i</sub> are color-coded to highlight specific pockets in yellow (0.5i<0.85). Highly specific subpockets are shown in red (S<sub>i</sub><0.5).</p
<p>(<b>a</b>) Overlay of prodomains from CspB <i>perfringens</i> (teal), Tk-SP (grey), and PCSK9 (pi...
Cysteine cathepsins mediate proteome homeostasis and have pivotal functions in diseases such as canc...
Cysteine cathepsins mediate proteome homeostasis and have pivotal functions in diseases such as canc...
<p>Subpocket-wise cleavage entropies S<sub>i</sub> of metallo proteases and associated MEROPS clans ...
<p>Further proteases in the test set and associated MEROPS clans not belonging to the catalytic type...
<p>Serine proteases and associated MEROPS clans sorted according to the number of known substrates n...
<p>Ranking of 49 proteases with respective MEROPS clan (including the added 2 glutamic proteases) in...
<p>Splitting of protease catalytic types into homologous protease clans allows to separate specific ...
<p>The degradome is mapped to a protease specificity tree based on S1 amino acid frequencies in subs...
<p>The degradome is mapped to a protease specificity tree based on local substrate similarity over S...
A purely information theory-guided approach to quantitatively characterize protease specificity is e...
<p>The degradome is mapped to a protease specificity tree based on substrate similarity over S4-S4′....
<div><p>A purely information theory-guided approach to quantitatively characterize protease specific...
<p>Eukaryotic proteases (3EST, 1TON, 3RP2, 5CHA) are in blue, prokaryotic (1SGT, 2SGA, 3SGB, 2ALP) i...
<p>Scattering of specific and unspecific behavior over respective evolutionary distances is apparent...
<p>(<b>a</b>) Overlay of prodomains from CspB <i>perfringens</i> (teal), Tk-SP (grey), and PCSK9 (pi...
Cysteine cathepsins mediate proteome homeostasis and have pivotal functions in diseases such as canc...
Cysteine cathepsins mediate proteome homeostasis and have pivotal functions in diseases such as canc...
<p>Subpocket-wise cleavage entropies S<sub>i</sub> of metallo proteases and associated MEROPS clans ...
<p>Further proteases in the test set and associated MEROPS clans not belonging to the catalytic type...
<p>Serine proteases and associated MEROPS clans sorted according to the number of known substrates n...
<p>Ranking of 49 proteases with respective MEROPS clan (including the added 2 glutamic proteases) in...
<p>Splitting of protease catalytic types into homologous protease clans allows to separate specific ...
<p>The degradome is mapped to a protease specificity tree based on S1 amino acid frequencies in subs...
<p>The degradome is mapped to a protease specificity tree based on local substrate similarity over S...
A purely information theory-guided approach to quantitatively characterize protease specificity is e...
<p>The degradome is mapped to a protease specificity tree based on substrate similarity over S4-S4′....
<div><p>A purely information theory-guided approach to quantitatively characterize protease specific...
<p>Eukaryotic proteases (3EST, 1TON, 3RP2, 5CHA) are in blue, prokaryotic (1SGT, 2SGA, 3SGB, 2ALP) i...
<p>Scattering of specific and unspecific behavior over respective evolutionary distances is apparent...
<p>(<b>a</b>) Overlay of prodomains from CspB <i>perfringens</i> (teal), Tk-SP (grey), and PCSK9 (pi...
Cysteine cathepsins mediate proteome homeostasis and have pivotal functions in diseases such as canc...
Cysteine cathepsins mediate proteome homeostasis and have pivotal functions in diseases such as canc...