Effect of catalase-transfected macrophages on inflammation and neurodegeneration in mice with PD model^a.

a<p>BALB/c mice were i.c. injected with 6-OHDA. Forty eight hours later, the animals were <i>i.v.</i> injected with various macrophage-based formulations or PBS. Control group was <i>i.c.</i> injected with PBS, and then 48 hours later <i>i.v.</i> injected with PBS.</p>b<p>Total number of neurons was calculated in ipsilateral hemisphere.</p>c<p>Statistical significance is shown by asterisk: <i>p</i><0.05 (*), and <i>p</i><0.005 (**) compared to mice with <i>i.c.</i> PBS injections followed by <i>i.v.</i> PBS injections (healthy controls); or <i>p</i><0.05 (#),compared to mice with <i>i.c.</i> 6-OHDA injections followed by <i>i.v.</i> PBS injections (PD controls); was performed by a1+standard t-test. Errors are mean ± SEM, <i>N</i> = 7.