Fold changes of serum metabolites in mice subjected to HFD or/and PFOA exposure for 3 weeks.

<p>Serum metabolites were analyzed by GC-TOF MS and HPLC-TOFMS (n = 7–8).</p>a<p>Fold change (FC) was obtained by comparing those metabolites in perfluorooctanoic acid (PFOA) group, high fat diet (HFD) group and HFD-PFOA group to control group (CTRL) or HFD-PFOA group to PFOA group; FC with a value >1 indicates a relatively higher concentration present in PFOA group, HFD group or HFD-PFOA group while a value <1 means a relatively lower concentration as compared to the controls or a relatively higher concentration present in HFD-PFOA group while a value <1 means a relatively lower concentration as compared to the PFOA group.</p>b<p><i>p</i> values from Student’s <i>t</i>-test.