Clinical evaluation of EAU after immunization.

<p>(<b>A</b>) Rats were immunized with IRBP (d0) to induce uveitis and intragastric administration (d1–d13) with leflunomide (low dose, 3 mg/kg; medium dose, 6 mg/kg; high dose, 12 mg/kg) or CsA (10 mg/kg). At the time of oral administration, mean clinical scores were recorded (d13) and are represented as mean clinical scores ±SD. Data presented are the average of six to eight rats per group. Clinical scores were calculated by the nonparametric Mann-Whitney <i>U</i> test. Statistical significance compared with vehicle is indicated by asterisks (*<i>P</i><0.05; **<i>P</i><0.01; ***<i>P</i><0.001). (<b>B</b>) The slit-lamp biomicroscopic of the eyes of different groups on day 14 after immunization. (a) Normal group rats eye showed normal iris vessels and red reflex. (b) Vehicle treated rats showed severe iris hyperemia and occlusion of pupil (c) leflunomide (low dose, 3 mg/kg). (d) leflunomide (medium dose, 6 mg/kg). (e) leflunomide (high dose, 12 mg/kg). (f) CsA (positive control, 10 mg/kg).