Effect of an intravitreal injection of glutamate without or with local HPC on retinal function.

<p>Eyes were intravitreally injected with vehicle or glutamate without or with local HPC applied 24 h before injections. Glutamate induced a significant decrease in the ERG b-wave and OP amplitude, whereas local HPC significantly prevented the effect of glutamate on these parameters. Upper panel: Average amplitudes of scotopic ERG a- and b-wave, and OP amplitudes. Shown are means ± SEM (n = 10 animals/group). *<i>P</i><0.05, and **<i>P</i><0.01, by Tukey’s test. Lower panel: Representative scotopic ERG and OP traces from eyes injected with glutamate without or with local HPC.