Clusterization of haplotypes reconstructed at the OARX locus.

<p>(A) Haplotypes determined in the French Grivette sheep population. (B) Haplotypes determined in the Polish Olkuska sheep population. 87 markers located in the interest OARX region (45 Mb–55 Mb) were selected to reconstruct haplotypes. Each column represents one SNP and each line represents one haplotype. For one marker (<i>i</i>) allele 1 is in red (Grivette) or green (Olkuska) in controls, respectively or black in cases, (<i>ii</i>) allele 2 is in white when the phase was unambiguous and (<i>iii</i>) dark grey colour represents unphased SNP. Haplotypes were ordered to distinguish controls versus cases and clusterized to classify similar clades of haplotypes. Markers with evidence of association at significance levels are marked with a star or a hash in French Grivette and Polish Olkuska sheep populations, respectively. In both breeds, the specific haplotype preferentially selected in highly prolific ewes (cases) is symbolized by red (Grivette) and green (Olkuska) boxes. The <i>BMP15</i> gene (48140251 bp–48146740 bp) is located between markers named OARX_6082722 and OARX_56342973.