Analysis of HIF-1α and ADORA2B in mucosa from the animal TNBS-induced colitis model with or without 5-ASA-treatment.

<p>6A) TNBS was associated with a significant elevation in HIF-1α and ADORA2B transcripts. Treatment with 5-ASA reversed these values to those similar to untreated rats. 6B) Protein expression was elevated by TNBS (HIF-1α: 1.68±0.11; ADORA2B: 1.37±0.09) and reversed by 5-ASA in mucosa. Mean±SEM, <i>n</i> = 3. *<i>p</i><0.05 versus control, **<i>p</i><0.05 versus TNBS.