Ligand-protein interaction diagram from the chymase-inhibitor (compound 1 in the training set of chymase).

<p>(<b>A</b>). The pharmacophore mapping of the same compound is also depicted. HBA, hydrogen bond acceptor; HY_AR, hydrophobic aromatic, HY_Al, hydrophobic aliphatic. The locations of amino acid residues are represented in rectangular boxes, where pink and green colors denote both the hydrogen bond acceptor/donor and nonpolar contacts, respectively (<b>B</b>) Correlation graph between experimental IC₅₀ and scale fit values.