Outer membrane protein changes and efflux pump expression together may confer resistance to ertapenem in Enterobacter cloacae
- Szabo, Dóra
- Silveira, Fernanda
- Hujer, Andrea M.
- Bonomo, Robert A.
- Hujer, Kristine M.
- Marsh, Jane W.
- Bethel, Christopher R.
- Doi, Yohei
- Deeley, Kathleen
- Paterson, David L.
Publication date
August 2006
DOI Publisher
American Society for Microbiology ISSN
0066-4804Abstract
We investigated ertapenem-susceptible and -resistant extended-spectrum β-lactamase-producing Enterobacter cloacae isolates obtained from the same patient. Gene transcription of OmpD and OmpF was diminished in the ertapenem-resistant isolate. An efflux pump inhibitor decreased the MICs of ertapenem in the resistant strain, suggesting a potential role of efflux pumps in ertapenem resistance. Copyright © 2006, American Society for Microbiology. All Rights Reserved
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