Item-wise correlations of brain activity with ratings of physical pain and emotional suffering.

<p>Regression analyses identified the brain regions where brain activity was most highly correlated with behavioral ratings of (A) “How much physical pain was the main character in?” (hot), and (B) “How much emotional suffering did the main character experience?” (cool). The brain regions where activity correlated with ratings of physical pain (A) include the bilateral insula cortex (Ins), anterior middle cingulate cortex (AMCC), bilateral middle frontal gyrus (MFG), bilateral secondary sensory regions (SII) and right extrastriate body area (EBA). The brain regions where activity correlated with ratings of emotional pain (suffering) (B) included the left dorsal striatum/anterior thalamus (Thal), precuneus (PC), posterior cingulate cortex (PCC), and regions in the medial prefrontal cortex (MPFC). Shown in (C) are both the regions where activity correlated with Pain (red), where activity correlated with Suffering (blue), and the conjunction of the two (white). All analyses are shown at p<0.05, corrected.