Ang II influences the production of perforin by splenic CD8⁺ T cellsduring <i>P. berghei</i> ANKA infection.

<p>T cells from naive mice and mice infected with <i>P. berghei</i> ANKA treated with vehicle, losartan or captopril by gavage were isolated at day 6 post infection, stained with fluorescent antibodies and analyzed by flow cytometry. (A) Representative dot plots of perforin⁺CD8⁺ T cells obtained from gated CD3⁺ cells. The percentage (B) and absolute number (<b>C</b>) of perforin⁺CD8⁺ T cells were determined. The results are expressed as means±SD. Statistically significant compared with values for *naive mice (<i>p</i><0.05) and #vehicle-treated mice infected with <i>P. berghei</i> ANKA (<i>p</i><0.05).