Ching001 inhibits colonization of A549 lung cancer cell in animal models without significant side effects.

<p>(<b>A</b>) A549 cells (1×10⁶) were tail vein injected into the BALB/c mice. The mice received 0.2 mg/kg Ching001 or 0.2 mg/kg Paclitaxel intraperitoneally every-other day for five weeks as indicated by arrow heads in lower right panel. Cells pretreated with 1 µM Ching001 before tail vein injection were also performed. DMSO was used as solvent control. The H&E-staining of the lung tissue (left), quantification of the tumor nodules in the lungs (upper right), and body weight (lower right) of A549 injected mice are shown. The red arrows indicated the sites of tumor nodules in the lung tissue. Original magnification×100. *: <i>P</i><0.05. (<b>B</b>) The hematology and biochemistry tests of blood from tested mice. In the hematology tests, WBC, RBC, and platelet were tested. In biochemistry tests, GOT, GPT, albumin, and total-bilirubin are used as indicators of liver function; BUN and creatinin as indicators of renal function. The data indicated that Ching001 treatment caused no apparent change on liver and kidney functions compared to DMSO-treated animals.