Structural comparison of integrin α1 and αIIb.

<p>Structure of α1-TMC (1135–1179) and backbone structure comparisons of α1-TM(1142–1169) with αIIb-TM structures indicate different bent regions in the transmembrane helix. The PDB number for each structure is listed below. (A) Structure ensemble of integrin α1-TMC in LDAO micelles; (B) Structure ensemble of integrin α1-TM in LDAO; (C) αIIb-TM (966–993) in bicelles <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0062954#pone.0062954-Lau3" target="_blank">[22]</a>; (D) αIIb-TM from IntαIIb/β3 complex in bicelles <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0062954#pone.0062954-Lau1" target="_blank">[20]</a>; (E) αIIb-TM (966–993) from αIIb/β3 complex in organic/aqueous solvents, 50% CD₃CN/50% H₂O <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0062954#pone.0062954-Yang1" target="_blank">[19]</a>.