Loss of <i>Apc</i> induced Notch1 activation in bronchiolar epithelium of <i>Apc^Foxj1</i> mice.

<p>Representative immunostaining of Ctnnb1 or CC10 (green) and cleaved Notch1 N–terminal intracellular domain (NICD) (red) in control (A–C and G–I) and <i>Apc^Foxj1</i> (D–F and J–L) lungs at postnatal 2 week-old. Empty arrows in D–F indicate co-localization of Ctnnb1 and NICD^pos cells. Arrows in D–F indicate NICD^pos cells in non-Ctnnb1cells. Empty arrows in J–L indicate NICD^pos cells in CC10<i>^Neg cells</i>. Arrows in J–L indicate co-localization of CC10 and NICD. Scale bar: 10 µm.