<p>(<b>A and B)</b> Representative current traces (comparison of taurine (600 mM) - and GABA (0.3–3 mM) - evoked maximal currents) are shown for different receptor types. (<b>A</b>) Concentration - response curves for the β<sub>1</sub> -containing receptors. Concentrations of agonist are plotted versus current amplitudes normalized on maximal GABA response (filled symbols for GABA -, open symbols for taurine - responses). Red curves are given for comparison with γ<sub>2</sub> (WT) - containing receptors. Note the dramatic increase in taurine efficacy over GABA in chimeric β<sub>1</sub> - containing GABA<sub>A</sub>R, which renders them similarity with the α<sub>2</sub>β<sub>1</sub>δ receptors.</p
Extrasynaptically located γ-aminobutyric acid (GABA) receptors type A are often characterized by the...
<p>(<b>A</b>) GABA concentration-response curve for α4β3N–Flag–δ receptor mediated currents. Current...
The aim of this study was to find taurinergic compounds that do not interact with brain GABA ergic s...
<p>Note that gating by taurine of γ<sub>2</sub> subunit containing GABA<sub>A</sub> receptors is sig...
<p>(<b>A</b>) Representative current traces show responses to the maximal GABA and taurine concentra...
<div><p>Taurine is a semi-essential sulfonic acid found at high concentrations in plasma and mammali...
Taurine is a semi-essential sulfonic acid found at high concentrations in plasma and mammalian tissu...
Taurine activates and modulates GABA receptors in vivo as well as those expressed in heterologous sy...
Taurine is a semi-essential sulfonic acid found at high concentrations in plasma and mammalian tissu...
<p>(<b>A</b>) Whole-cell voltage-clamp recordings (V<sub>h</sub> = −50 mV) from adult WT or KI mouse...
<p>GABA I <sub>max</sub> = 1; Responses to different taurine concentrations relative to I GABA max w...
Abstract Background The amino acid taurine (2-Aminoethanesulfonic acid) modulates inhibitory neurotr...
Taurine is one of the most abundant free amino acids in the brain. In a number of studies, taurine h...
Background: The amino acid taurine (2-Aminoethanesulfonic acid) modulates inhibitory neurotransmitte...
In the present study we have characterized the biophysical properties of wild-type (WT) α1β2 and α3β...
Extrasynaptically located γ-aminobutyric acid (GABA) receptors type A are often characterized by the...
<p>(<b>A</b>) GABA concentration-response curve for α4β3N–Flag–δ receptor mediated currents. Current...
The aim of this study was to find taurinergic compounds that do not interact with brain GABA ergic s...
<p>Note that gating by taurine of γ<sub>2</sub> subunit containing GABA<sub>A</sub> receptors is sig...
<p>(<b>A</b>) Representative current traces show responses to the maximal GABA and taurine concentra...
<div><p>Taurine is a semi-essential sulfonic acid found at high concentrations in plasma and mammali...
Taurine is a semi-essential sulfonic acid found at high concentrations in plasma and mammalian tissu...
Taurine activates and modulates GABA receptors in vivo as well as those expressed in heterologous sy...
Taurine is a semi-essential sulfonic acid found at high concentrations in plasma and mammalian tissu...
<p>(<b>A</b>) Whole-cell voltage-clamp recordings (V<sub>h</sub> = −50 mV) from adult WT or KI mouse...
<p>GABA I <sub>max</sub> = 1; Responses to different taurine concentrations relative to I GABA max w...
Abstract Background The amino acid taurine (2-Aminoethanesulfonic acid) modulates inhibitory neurotr...
Taurine is one of the most abundant free amino acids in the brain. In a number of studies, taurine h...
Background: The amino acid taurine (2-Aminoethanesulfonic acid) modulates inhibitory neurotransmitte...
In the present study we have characterized the biophysical properties of wild-type (WT) α1β2 and α3β...
Extrasynaptically located γ-aminobutyric acid (GABA) receptors type A are often characterized by the...
<p>(<b>A</b>) GABA concentration-response curve for α4β3N–Flag–δ receptor mediated currents. Current...
The aim of this study was to find taurinergic compounds that do not interact with brain GABA ergic s...