<p>The ability of the mTORC1 inhbitor rapamycin (A) and the mTORC1 and mTORC2 dual inhibitor Ku-0063794 (B) to inhibit growth of NRP-152 cells is revered by silencing Smads 2 and 3 (sh-S2+3) or by the TβRI/TβRII kinase dual inhibitor (TKDI), as assessed by cell growth after 6 days in GM3 medium. Although the Akt inhibitor MK2206 (0.5 µM) effectively represses LR3-IGF-I-induced cell growth in GM3 (C), TKDI reverses such suppression (D) as well as growth suppression (E) and Survivin suppression (F) by LY294002, rapamycin, U0126, MK2206 and Ku-0063794. D,E,F) Cells were plated in GM2.1 and pre-treated with TKDI or vehicle 4 h prior to treatment with the other kinase inhibitors. Cells were examined for cell growth after 5 days (by crystal viole...
BACKGROUND The effect of an EGF-R selective tyrosine kinase (EGF-RTK) quinazoline inhibitor ZM25286...
<p><b>A</b>) KGN cells were treated without (CTL) or with TGFα (10 ng/ml) in DMEM supplied with incr...
BACKGROUND The effect of an EGF-R selective tyrosine kinase (EGF-RTK) quinazoline inhibitor ZM25286...
<p>(A) Inhibition of autocrine TGF-β signaling reverses suppression of the Survivin promoter by anta...
<p>(A–C) TGF-β receptor kinase inhibitors stimulate the growth of NRP-152 cells. NRP-152 cells plate...
Deregulation of phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapa...
Although hyperactivated mTOR is well recognized as being pivotal to prostate cancer growth and progr...
Although hyperactivated mTOR is well recognized as being pivotal to prostate cancer growth and progr...
<p>(A) The indicated cell lines were treated with 2.5 ng/ml TGFβ, 100 nM rapamycin, or TGFβ + rapamy...
The phosphatidylinositol 3-kinase (PI3K)/serine-threonine kinase (Akt)/mammalian target of the rapam...
Abstract Background Transforming growth factor-β (TGFβ) plays an important role in late-stage carcin...
The vitamin D metabolite 1,25(OH)2D3 has long been known to inhibit growth of prostate cancer cells ...
The vitamin D metabolite 1,25(OH)2D3 has long been known to inhibit growth of prostate cancer cells ...
Survivin is a unique member of the inhibitor of apoptosis (IAP) proteins that is overexpressed in nu...
Abstract The TGF‐β type V receptor (TβR‐V) mediates growth inhibition by IGFBP‐3 and TGF‐β in epithe...
BACKGROUND The effect of an EGF-R selective tyrosine kinase (EGF-RTK) quinazoline inhibitor ZM25286...
<p><b>A</b>) KGN cells were treated without (CTL) or with TGFα (10 ng/ml) in DMEM supplied with incr...
BACKGROUND The effect of an EGF-R selective tyrosine kinase (EGF-RTK) quinazoline inhibitor ZM25286...
<p>(A) Inhibition of autocrine TGF-β signaling reverses suppression of the Survivin promoter by anta...
<p>(A–C) TGF-β receptor kinase inhibitors stimulate the growth of NRP-152 cells. NRP-152 cells plate...
Deregulation of phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapa...
Although hyperactivated mTOR is well recognized as being pivotal to prostate cancer growth and progr...
Although hyperactivated mTOR is well recognized as being pivotal to prostate cancer growth and progr...
<p>(A) The indicated cell lines were treated with 2.5 ng/ml TGFβ, 100 nM rapamycin, or TGFβ + rapamy...
The phosphatidylinositol 3-kinase (PI3K)/serine-threonine kinase (Akt)/mammalian target of the rapam...
Abstract Background Transforming growth factor-β (TGFβ) plays an important role in late-stage carcin...
The vitamin D metabolite 1,25(OH)2D3 has long been known to inhibit growth of prostate cancer cells ...
The vitamin D metabolite 1,25(OH)2D3 has long been known to inhibit growth of prostate cancer cells ...
Survivin is a unique member of the inhibitor of apoptosis (IAP) proteins that is overexpressed in nu...
Abstract The TGF‐β type V receptor (TβR‐V) mediates growth inhibition by IGFBP‐3 and TGF‐β in epithe...
BACKGROUND The effect of an EGF-R selective tyrosine kinase (EGF-RTK) quinazoline inhibitor ZM25286...
<p><b>A</b>) KGN cells were treated without (CTL) or with TGFα (10 ng/ml) in DMEM supplied with incr...
BACKGROUND The effect of an EGF-R selective tyrosine kinase (EGF-RTK) quinazoline inhibitor ZM25286...