Experimental design.

Effect of exercise training and carvedilol treatment on cardiac function and structure in mice with sympathetic hyperactivity-induced heart failure

MEDEIRO, A.
VANZELLI, A.S.
ROSA, K.T.
IRIGOYEN, M.C.
BRUM, P.C.

January 2008

The present investigation was undertaken to study the effect of β-blockers and exercise trainin...

Supplemental Experimental Procedures Animals

Allison C. Gates
Carlos Bernal-mizrachi
Sharon L. Chinault
Chu Feng
Jochen G
Trey Coleman
James P. Malone
R. Reid Townsend
Manu V. Chakravarthy
Clay F. Semenkovich

January 2015

were housed in a specific pathogen-free barrier facility with free access to water. For the longevit...

Exercise training reduced the myocardial hypertrophy induced by isoproterenol.

Liang Yang (15035)
Zhe Jia (408491)
Lei Yang (102719)
Mengmeng Zhu (378801)
Jincai Zhang (341525)
Jie Liu (15128)
Ping Wu (46628)
Wencong Tian (561205)
Jing Li (10611)
Zhi Qi (160852)
Xiangdong Tang (561206)

May 2014

Mice were housed in cages fitted with running wheels and allowed to exercise training for 4 weeks...

Heart rate (A) and blood pressure (B) during interventions in control (WT), heart failure placebo (KOS), heart failure exercise trained (KOT), heart failure carvedilol-treated (KOC) and, heart failure carvedilol-treated and exercise-trained (KOCT) mice.

Andréa S. Vanzelli (409055)
Alessandra Medeiros (409056)
Natale Rolim (409057)
Jan B. Bartholomeu (409058)
Telma F. Cunha (145298)
Luiz G. Bechara (409059)
Enéas R. M. Gomes (409060)
Katt C. Mattos (409061)
Raquel Sirvente (409062)
Vera Salemi (409063)
Charles Mady (59479)
Carlos E. Negrao (5654803)
Silvia Guatimosim (154143)
Patricia C. Brum (145324)

May 2013

Note that all interventions decreased to the same extent the baseline HR of KO mice, which became...

Lipid peroxidation in control (WT), heart failure placebo (KOS), heart failure exercise trained (KOT), heart failure carvedilol-treated (KOC) and, heart failure carvedilol-treated and exercise trained (KOCT) mice.

Andréa S. Vanzelli (409055)
Alessandra Medeiros (409056)
Natale Rolim (409057)
Jan B. Bartholomeu (409058)
Telma F. Cunha (145298)
Luiz G. Bechara (409059)
Enéas R. M. Gomes (409060)
Katt C. Mattos (409061)
Raquel Sirvente (409062)
Vera Salemi (409063)
Charles Mady (59479)
Carlos E. Negrao (5654803)
Silvia Guatimosim (154143)
Patricia C. Brum (145324)

May 2013

Data are presented as mean ± SE. The number of animals studied is indicated by numerals on the ab...

Cardiomyocytes cross-sectional area (A) and ventricular collagen volume fraction (B) in control (WT), heart failure placebo (KOS), heart failure exercise trained (KOT), heart failure carvedilol-treated (KOC) and, heart failure carvedilol-treated and exercise trained (KOCT) mice.

Andréa S. Vanzelli (409055)
Alessandra Medeiros (409056)
Natale Rolim (409057)
Jan B. Bartholomeu (409058)
Telma F. Cunha (145298)
Luiz G. Bechara (409059)
Enéas R. M. Gomes (409060)
Katt C. Mattos (409061)
Raquel Sirvente (409062)
Vera Salemi (409063)
Charles Mady (59479)
Carlos E. Negrao (5654803)
Silvia Guatimosim (154143)
Patricia C. Brum (145324)

May 2013

Data are presented as mean ± SE. The number of animals studied is indicated by numerals on the ab...

Survival (A), Exercise tolerance (B) and fractional shortening (FS, C) in control (WT), heart failure placebo (KOS), heart failure exercise trained (KOT), heart failure carvedilol-treated (KOC) and, heart failure carvedilol-treated and exercise trained (KOCT) mice.

Andréa S. Vanzelli (409055)
Alessandra Medeiros (409056)
Natale Rolim (409057)
Jan B. Bartholomeu (409058)
Telma F. Cunha (145298)
Luiz G. Bechara (409059)
Enéas R. M. Gomes (409060)
Katt C. Mattos (409061)
Raquel Sirvente (409062)
Vera Salemi (409063)
Charles Mady (59479)
Carlos E. Negrao (5654803)
Silvia Guatimosim (154143)
Patricia C. Brum (145324)

May 2013

FS was evaluated after 8 weeks of intervention. Note that all interventions reduced mortality rat...

Effect of exercise training and carvedilol treatment on cardiac function and structure in mice with sympathetic hyperactivity-induced heart failure

MEDEIRO, A.
VANZELLI, A.S.
ROSA, K.T.
IRIGOYEN, M.C.
BRUM, P.C.

January 2008

The present investigation was undertaken to study the effect of β-blockers and exercise trainin...

Effect of exercise training and carvedilol treatment on cardiac function and structure in mice with sympathetic hyperactivity-induced heart failure

MEDEIRO, A.
VANZELLI, A.S.
ROSA, K.T.
IRIGOYEN, M.C.
BRUM, P.C.

January 2008

The present investigation was undertaken to study the effect of β-blockers and exercise trainin...

Integrative effect of carvedilol and aerobic exercise training therapies on improving cardiac contractility and remodeling in heart failure mice

Vanzelli, Andréa S.
Medeiros, Alessandra
Rolim, Natale Pinheiro Lage
Bartholomeu, Jan B.
Cunha, Telma F.
Bechara, Luiz G.
Gomes, Enéas R.M.
Mattos, Katt C.
Sirvente, Raquel
Salemi, Vera
Mady, Charles
Negrao, Carlos E.
Guatimosim, Silvia
Brum, Patricia C.

January 2013

The use of β-blockers is mandatory for counteracting heart failure (HF)-induced chronic sympathetic ...

Cardiac function in treated mdx mice in the first series of experiments.

Yeranuhi Hovhannisyan (6623378)
Gagik Melikyan (6623381)
Nathalie Mougenot (6623384)
Jacqueline Gao-Li (6623387)
Bertrand Friguet (687284)
Denise Paulin (47703)
Zhenlin Li (497813)
Arnaud Ferry (115605)
Onnik Agbulut (171660)

April 2019

Left ventricular ejection fraction (EF); Left ventricular shortening fraction (FS). Sed: non-treated...

Study design.

Heidi Ehrentraut (77283)
Stefan Felix Ehrentraut (136865)
Olaf Boehm (136875)
Sakina El Aissati (829008)
Fabian Foltz (829009)
Lina Goelz (829010)
David Goertz (829011)
Sied Kebir (829012)
Christina Weisheit (416030)
Michael Wolf (15932)
Rainer Meyer (33119)
Georg Baumgarten (33122)

November 2015

3 d after TAC or sham surgery mice were challenged with CpG-ODN 1668 thioate, LTA or PBS as contr...

SIRT3-KO mice had a propensity to develop heart failure in response to TAC.

Tongshuai Chen (699646)
Junni Liu (699647)
Na Li (6550)
Shujian Wang (699648)
Hui Liu (33624)
Jingyuan Li (53885)
Yun Zhang (131894)
Peili Bu (699649)

March 2015

(A) SIRT3 protein was absent in the hearts from SIRT3-KO mice. The protein extracts were probed w...

RNA-Seq experiment using a mouse heart failure model generated on two genotypes.

Xiaoke Ma (756313)
Long Gao (108662)
Georgios Karamanlidis (756314)
Peng Gao (35465)
Chi Fung Lee (423301)
Lorena Garcia-Menendez (756315)
Rong Tian (397491)
Kai Tan (108663)

June 2015

A, Time-course RNA-Seq data were generated using mouse hearts perturbed by stress (TAC) or geneti...

Integrative Effect of Carvedilol and Aerobic Exercise Training Therapies on Improving Cardiac Contractility and Remodeling in Heart Failure Mice

Andréa S. Vanzelli
Ra Medeiros
Natale Rolim
Jan B. Bartholomeu
Telma F. Cunha
Luiz G. Bechara
Enéas R. M. Gomes
Katt C. Mattos
Raquel Sirvente
Vera Salemi
Charles Mady
Carlos E. Negrao
Silvia Guatimosim
Patricia C. Brum

August 2016

The use of b-blockers is mandatory for counteracting heart failure (HF)-induced chronic sympathetic ...

Effect of exercise training and carvedilol treatment on cardiac function and structure in mice with sympathetic hyperactivity-induced heart failure

MEDEIRO, A.
VANZELLI, A.S.
ROSA, K.T.
IRIGOYEN, M.C.
BRUM, P.C.

January 2008

The present investigation was undertaken to study the effect of β-blockers and exercise trainin...

Supplemental Experimental Procedures Animals

Allison C. Gates
Carlos Bernal-mizrachi
Sharon L. Chinault
Chu Feng
Jochen G
Trey Coleman
James P. Malone
R. Reid Townsend
Manu V. Chakravarthy
Clay F. Semenkovich

January 2015

were housed in a specific pathogen-free barrier facility with free access to water. For the longevit...

Exercise training reduced the myocardial hypertrophy induced by isoproterenol.

Liang Yang (15035)
Zhe Jia (408491)
Lei Yang (102719)
Mengmeng Zhu (378801)
Jincai Zhang (341525)
Jie Liu (15128)
Ping Wu (46628)
Wencong Tian (561205)
Jing Li (10611)
Zhi Qi (160852)
Xiangdong Tang (561206)

May 2014

Mice were housed in cages fitted with running wheels and allowed to exercise training for 4 weeks...

Heart rate (A) and blood pressure (B) during interventions in control (WT), heart failure placebo (KOS), heart failure exercise trained (KOT), heart failure carvedilol-treated (KOC) and, heart failure carvedilol-treated and exercise-trained (KOCT) mice.

Andréa S. Vanzelli (409055)
Alessandra Medeiros (409056)
Natale Rolim (409057)
Jan B. Bartholomeu (409058)
Telma F. Cunha (145298)
Luiz G. Bechara (409059)
Enéas R. M. Gomes (409060)
Katt C. Mattos (409061)
Raquel Sirvente (409062)
Vera Salemi (409063)
Charles Mady (59479)
Carlos E. Negrao (5654803)
Silvia Guatimosim (154143)
Patricia C. Brum (145324)

May 2013

Note that all interventions decreased to the same extent the baseline HR of KO mice, which became...

Lipid peroxidation in control (WT), heart failure placebo (KOS), heart failure exercise trained (KOT), heart failure carvedilol-treated (KOC) and, heart failure carvedilol-treated and exercise trained (KOCT) mice.

Andréa S. Vanzelli (409055)
Alessandra Medeiros (409056)
Natale Rolim (409057)
Jan B. Bartholomeu (409058)
Telma F. Cunha (145298)
Luiz G. Bechara (409059)
Enéas R. M. Gomes (409060)
Katt C. Mattos (409061)
Raquel Sirvente (409062)
Vera Salemi (409063)
Charles Mady (59479)
Carlos E. Negrao (5654803)
Silvia Guatimosim (154143)
Patricia C. Brum (145324)

May 2013

Data are presented as mean ± SE. The number of animals studied is indicated by numerals on the ab...

Cardiomyocytes cross-sectional area (A) and ventricular collagen volume fraction (B) in control (WT), heart failure placebo (KOS), heart failure exercise trained (KOT), heart failure carvedilol-treated (KOC) and, heart failure carvedilol-treated and exercise trained (KOCT) mice.

Andréa S. Vanzelli (409055)
Alessandra Medeiros (409056)
Natale Rolim (409057)
Jan B. Bartholomeu (409058)
Telma F. Cunha (145298)
Luiz G. Bechara (409059)
Enéas R. M. Gomes (409060)
Katt C. Mattos (409061)
Raquel Sirvente (409062)
Vera Salemi (409063)
Charles Mady (59479)
Carlos E. Negrao (5654803)
Silvia Guatimosim (154143)
Patricia C. Brum (145324)

May 2013

Data are presented as mean ± SE. The number of animals studied is indicated by numerals on the ab...

Survival (A), Exercise tolerance (B) and fractional shortening (FS, C) in control (WT), heart failure placebo (KOS), heart failure exercise trained (KOT), heart failure carvedilol-treated (KOC) and, heart failure carvedilol-treated and exercise trained (KOCT) mice.

Andréa S. Vanzelli (409055)
Alessandra Medeiros (409056)
Natale Rolim (409057)
Jan B. Bartholomeu (409058)
Telma F. Cunha (145298)
Luiz G. Bechara (409059)
Enéas R. M. Gomes (409060)
Katt C. Mattos (409061)
Raquel Sirvente (409062)
Vera Salemi (409063)
Charles Mady (59479)
Carlos E. Negrao (5654803)
Silvia Guatimosim (154143)
Patricia C. Brum (145324)

May 2013

FS was evaluated after 8 weeks of intervention. Note that all interventions reduced mortality rat...

Effect of exercise training and carvedilol treatment on cardiac function and structure in mice with sympathetic hyperactivity-induced heart failure

MEDEIRO, A.
VANZELLI, A.S.
ROSA, K.T.
IRIGOYEN, M.C.
BRUM, P.C.

January 2008

The present investigation was undertaken to study the effect of β-blockers and exercise trainin...

Effect of exercise training and carvedilol treatment on cardiac function and structure in mice with sympathetic hyperactivity-induced heart failure

MEDEIRO, A.
VANZELLI, A.S.
ROSA, K.T.
IRIGOYEN, M.C.
BRUM, P.C.

January 2008

The present investigation was undertaken to study the effect of β-blockers and exercise trainin...

Integrative effect of carvedilol and aerobic exercise training therapies on improving cardiac contractility and remodeling in heart failure mice

Vanzelli, Andréa S.
Medeiros, Alessandra
Rolim, Natale Pinheiro Lage
Bartholomeu, Jan B.
Cunha, Telma F.
Bechara, Luiz G.
Gomes, Enéas R.M.
Mattos, Katt C.
Sirvente, Raquel
Salemi, Vera
Mady, Charles
Negrao, Carlos E.
Guatimosim, Silvia
Brum, Patricia C.

January 2013

The use of β-blockers is mandatory for counteracting heart failure (HF)-induced chronic sympathetic ...

Cardiac function in treated mdx mice in the first series of experiments.

Yeranuhi Hovhannisyan (6623378)
Gagik Melikyan (6623381)
Nathalie Mougenot (6623384)
Jacqueline Gao-Li (6623387)
Bertrand Friguet (687284)
Denise Paulin (47703)
Zhenlin Li (497813)
Arnaud Ferry (115605)
Onnik Agbulut (171660)

April 2019

Left ventricular ejection fraction (EF); Left ventricular shortening fraction (FS). Sed: non-treated...

Study design.

Heidi Ehrentraut (77283)
Stefan Felix Ehrentraut (136865)
Olaf Boehm (136875)
Sakina El Aissati (829008)
Fabian Foltz (829009)
Lina Goelz (829010)
David Goertz (829011)
Sied Kebir (829012)
Christina Weisheit (416030)
Michael Wolf (15932)
Rainer Meyer (33119)
Georg Baumgarten (33122)

November 2015

3 d after TAC or sham surgery mice were challenged with CpG-ODN 1668 thioate, LTA or PBS as contr...

SIRT3-KO mice had a propensity to develop heart failure in response to TAC.

Tongshuai Chen (699646)
Junni Liu (699647)
Na Li (6550)
Shujian Wang (699648)
Hui Liu (33624)
Jingyuan Li (53885)
Yun Zhang (131894)
Peili Bu (699649)

March 2015

(A) SIRT3 protein was absent in the hearts from SIRT3-KO mice. The protein extracts were probed w...

RNA-Seq experiment using a mouse heart failure model generated on two genotypes.

Xiaoke Ma (756313)
Long Gao (108662)
Georgios Karamanlidis (756314)
Peng Gao (35465)
Chi Fung Lee (423301)
Lorena Garcia-Menendez (756315)
Rong Tian (397491)
Kai Tan (108663)

June 2015

A, Time-course RNA-Seq data were generated using mouse hearts perturbed by stress (TAC) or geneti...

Integrative Effect of Carvedilol and Aerobic Exercise Training Therapies on Improving Cardiac Contractility and Remodeling in Heart Failure Mice

Andréa S. Vanzelli
Ra Medeiros
Natale Rolim
Jan B. Bartholomeu
Telma F. Cunha
Luiz G. Bechara
Enéas R. M. Gomes
Katt C. Mattos
Raquel Sirvente
Vera Salemi
Charles Mady
Carlos E. Negrao
Silvia Guatimosim
Patricia C. Brum

August 2016

The use of b-blockers is mandatory for counteracting heart failure (HF)-induced chronic sympathetic ...

Effect of exercise training and carvedilol treatment on cardiac function and structure in mice with sympathetic hyperactivity-induced heart failure

MEDEIRO, A.
VANZELLI, A.S.
ROSA, K.T.
IRIGOYEN, M.C.
BRUM, P.C.

January 2008

The present investigation was undertaken to study the effect of β-blockers and exercise trainin...

Supplemental Experimental Procedures Animals

Allison C. Gates
Carlos Bernal-mizrachi
Sharon L. Chinault
Chu Feng
Jochen G
Trey Coleman
James P. Malone
R. Reid Townsend
Manu V. Chakravarthy
Clay F. Semenkovich

January 2015

were housed in a specific pathogen-free barrier facility with free access to water. For the longevit...

Exercise training reduced the myocardial hypertrophy induced by isoproterenol.

Liang Yang (15035)
Zhe Jia (408491)
Lei Yang (102719)
Mengmeng Zhu (378801)
Jincai Zhang (341525)
Jie Liu (15128)
Ping Wu (46628)
Wencong Tian (561205)
Jing Li (10611)
Zhi Qi (160852)
Xiangdong Tang (561206)

May 2014

Mice were housed in cages fitted with running wheels and allowed to exercise training for 4 weeks...

Experimental design.

Abstract

Extracted data

Experimental design.

Abstract

Extracted data

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