CD8^−/− increased the production of pro-inflammatory cytokines.

<p>A. <i>In vivo</i>, expression of inflammatory factors (TNF-α, IL-6, MCP-1) mRNA in injured femoral arteries from WT and CD8^−/− mice at day 1 or day 7 time point after wire injury. Expression of inflammatory factors mRNA was analyzed by quantitative RT-PCR. The level of expression was normalized to that of β-tubulin. *<i>P</i><0.05 versus WT mice, n = 4. B. <i>In vitro</i>, WT T cells or CD8^−/− T cells were co-cultured with WT Mφ, and the level of TNF-α production in the medium was measured by CBA. ^##<i>P</i><0.01 versus WT T cell group; ^**<i>P</i><0.01 versus WT Mφ+CD8^−/− T cell group,n = 5. Mφ, Macrophage.