Mean progression , as a function of relative signaling rate , and relative degradation rate .

<p>(A) as a function of . Error bars are obtained from many numerical realizations (between ) and represent the standard error of the mean. In the top panel, the degradation rate is comparable to the experimentally obtained degradation of the phosphodiesterase. In the bottom panel, we used small cAMP degradation rate, which models the mutant PDE1- cells, incapable of secreting the enzyme that degrades cAMP. (B) as a function of the relative cAMP secretion and relative cAMP degradation rates. The red regions correspond to uncorrelated motion. The dynamically unstable regions, where streams are likely to form, of the (, ) phase space is labeled with yellow and white. Blue regions are associated with aggregate formation.