Analysis of culture results as surrogate endpoints across all trials.

<p><b>A</b>. Month 1 (a positive culture with heavy growth, at least 20 colonies), R²_trial = 0.36. <b>B</b>. Month 2 (a positive culture with any growth), R²_trial = 0.36. <b>C</b>. Month 3 (a positive culture with any growth), R²_trial = 0.69. Logs odds ratio of a poor outcome plotted against log odds ratio of a positive culture. Fitted line is weighted by the precision of the estimates, and this precision is represented by the diameter of the circles around each point. The dotted line represents the 95% confidence interval on the slope.