Heatmap representing the expressions of 59 genes with significant different expression in CUP compared with other cancer types or normal lymph nodes.

<p>Genes are indicated on the right. The colored bar above the heatmap represents the different cancer types, and the legend key is on the left. On the heatmap, red represents up-regulated genes and green represents down-regulated genes, relative to the expression levels in normal lymph nodes, with the scale shown in the upper left corner. The gene expression profiling datasets for normal lymph nodes and 24 known cancer types other than CUP were obtained from publicly available sources, as described in the Materials and Methods.