Trabecular bone volume is reduced in <i>Pin1</i> KO mice.

<p>3D µCT reconstruction and slice of representative femurs and vertebral sections from 4 month-old mice. (<b>A</b>) Femoral bone parameters were determined with 3D construction using Amira and ImageJ softwares. Upper right: Cross-sectional slice at mid-diaphysis from each femur. (<b>B</b> and <b>C</b>) Trabecular bone volume (BV/TV) of the distal end of femurs (<b>B</b>) and the lumbar vertebra (L4) (<b>C</b>) was quantified as described in the Methods after slicing the 3D construction in longitude direction. *denotes p<0.05 by paired student t-test with 8 mice per group.