TLR4 deficiency protects against PCB153-NP-induced expression of proinflammatory genes in brain microvessels.

<p>Mice were treated as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0063159#pone-0063159-g001" target="_blank">Figure 1</a>. mRNA levels of IL-6, ICAM-1, CCL-2 (MCP-1) and CCL-5 (RANTES) were determined in isolated brain microvessels by real-time PCR. Results are means ± SEM, n = 5. Significantly different as compared to vehicle treatments in normal mice at *p<0.05, or ***p<0.001. Results in the TLR4-deficient mice treated with PCB153-NPs are statistically different from those in control animals exposed to PCB153-NPs at ^#p<0.05 or ^###p<0.001.