Gap junction opener TriMA enhances seizure-like activity.

<p>(A) Typical example of ensemble seizure-like activity. The channel surrounded by the blue square is magnified in B. (B) Typical seizure-like activity showed that the application of 5 mM TriMA enhanced the clonic phase of seizure-like activity (red lines). The effects of TriMA were reversible. Brain slice washes with 4-AP and bicuculline restored seizure-like activity to original levels. (C) The statistical results showed that the amplitude of seizure-like activity was not changed by TriMA in either the ictal-tonic or clonic phase. The duration of the ictal-tonic phase was significantly enhanced after 5 mM TriMA application. The clonic phase was enhanced by 3 mM TriMA application. Cx, cortex; Str, striatum; Th, thalamus.