<b>Schematic of mature, anagen hair follicle (HF) morphology with typical localization of keratinocytic lineage progeny in wild type (WT).</b>

<p>CD49f/α6-integrin (blue) positive epithelium dominates within the basal layer of the surface epithelium. CD200 (purple) and CD34 (red) are both strongly expressed within the bulge region. In addition, CD200 is also expressed in upper parts of the outer root sheet (ORS) whereas CD34 expression may extend below the bulge region. Matrix cells of the hair bulb are considered CD49f/CD200/CD34 negative. In general, surface markers of epithelial progeny are not exclusive for each other in part depending on the stage of hair cycling. This study evaluates various effects of Foxn1 loss-of-function on telogen-anagen hair cycling and epithelial stem cell niche regulation in Nu/Nu mice.