<b>Schematic of the effects of Foxn1 loss-of-function on keratinocytic lineage differentiation in nude mice.</b>

<p>(A) A severe disturbance in keratin synthesis and terminal differentiation in the Foxn1^−/− phenotype also affects upstream lineage progenitors with strong upregulation of Lhx2 as a key feature. (B) Altered Wnt- and Shh-signaling in the Foxn1^−/− phenotype.