Estimates of additive and non-additive genetic components of transcript expression levels estimated using genetically orthogonal approaches in related and unrelated individuals.

Expression estimates using personalized HLA genotypes (x-axis) versus the reference transcriptome (y-axis) in the index.

Vitor R. C. Aguiar (6619328)
Jônatas César (5448176)
Olivier Delaneau (76754)
Emmanouil T. Dermitzakis (120302)
Diogo Meyer (231695)

April 2019

For each individual we identify the average divergence (proportion of mismatches) with respect to th...

Integrating genome-wide genetic variations and monocyte expression data reveals transregulated gene modules in humans. PLoS Genet doi:10.1371/journal

Maxime Rotival
Tanja Zeller
Seraya Maouche
Silke Szymczak
Arne Schillert
Carole Proust
Jessy Brocheton
Tiphaine Godefroy
Claire Perret
Marine Germain
Medea Eleftheriadis
Christoph R. Sinning
Renate B. Schnabel
Edith Lubos
Karl J
Heidi Rossmann
Augusto Rendon
Cardiogenics Consortium
Panos Deloukas
Christian Hengstenberg
Patrick Diemert
Gilles Montalescot
Willem H
Nilesh J. Samani
Heribert Schunkert
Re Tregouet
Andreas Ziegler
Alison H. Goodall
Laurence Tiret
Stefan Blankenberg

January 2011

One major expectation from the transcriptome in humans is to characterize the biological basis of as...

An approach for joint quantitative analysis of gene expression and regulatory QTLs.

Athma A. Pai (119315)
Jonathan K. Pritchard (113911)
Yoav Gilad (2481)

January 2015

<p>A goal of interindividual studies of regulatory mechanisms is to understand the extent to which v...

Congruence of Additive and Non-Additive Effects on Gene Expression Estimated from Pedigree and SNP Data

Joseph E. Powell (168647)
Anjali K. Henders (168652)
Allan F. McRae (168656)
Jinhee Kim (233831)
Gibran Hemani (208828)
Nicholas G. Martin (113568)
Emmanouil T. Dermitzakis (120302)
Greg Gibson (4110)
Grant W. Montgomery (131518)
Peter M. Visscher (16568)

May 2013

<div><p>There is increasing evidence that heritable variation in gene expression underlies genetic v...

Identifying Dominant Genetic Associations with Gene Expression in the Human Genome

GU, JING

January 2017

When mapping expression quantitative trait loci, a linear additive genetic model is mostly commonly ...

Congruence of additive and non-additive effects on gene expression estimated from pedigree and SNP data

Powell, Joseph E.
Henders, Anjali K.
McRae, Allan F.
Kim, Jinhee
Hemani, Gibran
Martin, Nicholas G.
Dermitzakis, Emmanouil T.
Gibson, Greg
Montgomery, Grant W.
Visscher, Peter M.

May 2013

There is increasing evidence that heritable variation in gene expression underlies genetic variation...

B (2005) The quantitative genetics of transcription

Greg Gibson
Bruce Weir

September 2016

Quantitative geneticists have become interested in the heritability of transcription and detection o...

Variance analysis and classification of phenotypically plastic and robust transcripts.

Shanshan Zhou (175668)
Terry G. Campbell (175675)
Eric A. Stone (120305)
Trudy F. C. Mackay (120308)
Robert R. H. Anholt (159214)

March 2012

<p>(A, B) Relationships between coefficients of genetic variance of inbred lines (CVL) and coefficie...

INVESTIGATION HIGHLIGHTED ARTICLE Additive, Epistatic, and Environmental Effects Through the Lens of Expression Variability QTL in a Twin Cohort

January 2016

ABSTRACT The expression of a gene can vary across individuals in the general population, as well as ...

Accounting for non-genetic factors improves the power of eQTL studies

Oliver Stegle
Anitha Kannan
Richard Durbin
John Winn

January 2008

Abstract. The recent availability of large scale data sets profiling sin-gle nucleotide polymorphism...

A Bayesian Framework to Account for Complex Non-Genetic Factors in Gene Expression Levels Greatly Increases Power in eQTL Studies

Stegle, O.
Parts, L.
Durbin, R.
Winn, J.

May 2010

Gene expression measurements are influenced by a wide range of factors, such as the state of the cel...

Diagnostics plots for processing pipeline.

Scott Wolf (9113613)
Diogo Melo (3289926)
Kristina M. Garske (11220178)
Luisa F. Pallares (7877681)
Amanda J. Lea (11790137)
Julien F. Ayroles (10580370)

July 2023

Gene expression variance has been linked to organismal function and fitness but remains a commonly n...

Discovery and overlap of expression QTLs and variance QTLs.

Abhishek K. Sarkar (6616010)
Po-Yuan Tung (6616013)
John D. Blischak (631103)
Jonathan E. Burnett (6616016)
Yang I. Li (6616019)
Matthew Stephens (3815)
Yoav Gilad (2481)

April 2019

(A) z-scores for expression QTL (eQTL) SNP-gene pairs discovered in pooled single cell RNA-seq data ...

Genome-Wide Expression Quantitative Trait Loci Analysis Using Mixed Models

Chaeyoung Lee

August 2018

Expression quantitative trait loci (eQTLs) are important for understanding the genetic basis of cell...

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

Vosa, U
Claringbould, A
Westra, HJ
Bonder, MJ
Deelen, P
Zeng, B
Kirsten, H
Saha, A
Kreuzhuber, R
Yazar, S
Brugge, H
Oelen, R
de Vries, DH
van der Wijst, MGP
Kasela, S
Pervjakova, N
Alves, I
Favve, MJ
Agbessi, M
Christiansen, MW
Jansen, R
Seppala, I
Tong, L
Teumer, A
Schramm, K
Hemani, G
Verlouw, J
Yaghootkar, H
Sonmez Flitman, R
Brown, A
Kukushkina, V
Kalnapenkis, A
Rueger, S
Porcu, E
Kronberg, J
Kettunen, J
Lee, B
Zhang, F
Qi, T
Hernandez, JA
Arindrarto, W
Beutner, F
Dmitrieva, J
Elansary, M
Fairfax, BP
Georges, M
Hewitt, AW
Heijmans, BT
Kahonen, M
Kim, Y
Knight, JC
Kovacs, P
Krohn, K
Li, S
Loeffler, M
Marigorta, UM
Mei, H
Momozawa, Y
Muller-Nurasyid, M
Nauck, M
Nivard, MG
Penninx, BWJH
Pritchard, JK
Raitakari, OT
Rotzschke, O
Slagboom, EP
Stehouwer, CDA
Stumvoll, M
Sullivan, P
't Hoen, PAC
Thiery, J
Tonjes, A
van Dongen, J
van Iterson, M
Veldink, JH
Volker, U
Warmerdam, R
Wijmenga, C
Swertz, M
Andiappan, A
Montgomery, GW
Ripatti, S
Perola, M
Kutalik, Z
Dermitzakis, E
Bergmann, S
Frayling, T
van Meurs, J
Prokisch, H
Ahsan, H
Pierce, BL
Lehtimaki, T
Boomsma, DI
Psaty, BM
Gharib, SA
Awadalla, P
Milani, L
Ouwehand, WH
Downes, K

January 2021

Trait-associated genetic variants affect complex phenotypes primarily via regulatory mechanisms on t...

Expression estimates using personalized HLA genotypes (x-axis) versus the reference transcriptome (y-axis) in the index.

Vitor R. C. Aguiar (6619328)
Jônatas César (5448176)
Olivier Delaneau (76754)
Emmanouil T. Dermitzakis (120302)
Diogo Meyer (231695)

April 2019

For each individual we identify the average divergence (proportion of mismatches) with respect to th...

Integrating genome-wide genetic variations and monocyte expression data reveals transregulated gene modules in humans. PLoS Genet doi:10.1371/journal

Maxime Rotival
Tanja Zeller
Seraya Maouche
Silke Szymczak
Arne Schillert
Carole Proust
Jessy Brocheton
Tiphaine Godefroy
Claire Perret
Marine Germain
Medea Eleftheriadis
Christoph R. Sinning
Renate B. Schnabel
Edith Lubos
Karl J
Heidi Rossmann
Augusto Rendon
Cardiogenics Consortium
Panos Deloukas
Christian Hengstenberg
Patrick Diemert
Gilles Montalescot
Willem H
Nilesh J. Samani
Heribert Schunkert
Re Tregouet
Andreas Ziegler
Alison H. Goodall
Laurence Tiret
Stefan Blankenberg

January 2011

One major expectation from the transcriptome in humans is to characterize the biological basis of as...

An approach for joint quantitative analysis of gene expression and regulatory QTLs.

Athma A. Pai (119315)
Jonathan K. Pritchard (113911)
Yoav Gilad (2481)

January 2015

<p>A goal of interindividual studies of regulatory mechanisms is to understand the extent to which v...

Congruence of Additive and Non-Additive Effects on Gene Expression Estimated from Pedigree and SNP Data

Joseph E. Powell (168647)
Anjali K. Henders (168652)
Allan F. McRae (168656)
Jinhee Kim (233831)
Gibran Hemani (208828)
Nicholas G. Martin (113568)
Emmanouil T. Dermitzakis (120302)
Greg Gibson (4110)
Grant W. Montgomery (131518)
Peter M. Visscher (16568)

May 2013

<div><p>There is increasing evidence that heritable variation in gene expression underlies genetic v...

Identifying Dominant Genetic Associations with Gene Expression in the Human Genome

GU, JING

January 2017

When mapping expression quantitative trait loci, a linear additive genetic model is mostly commonly ...

Congruence of additive and non-additive effects on gene expression estimated from pedigree and SNP data

Powell, Joseph E.
Henders, Anjali K.
McRae, Allan F.
Kim, Jinhee
Hemani, Gibran
Martin, Nicholas G.
Dermitzakis, Emmanouil T.
Gibson, Greg
Montgomery, Grant W.
Visscher, Peter M.

May 2013

There is increasing evidence that heritable variation in gene expression underlies genetic variation...

B (2005) The quantitative genetics of transcription

Greg Gibson
Bruce Weir

September 2016

Quantitative geneticists have become interested in the heritability of transcription and detection o...

Variance analysis and classification of phenotypically plastic and robust transcripts.

Shanshan Zhou (175668)
Terry G. Campbell (175675)
Eric A. Stone (120305)
Trudy F. C. Mackay (120308)
Robert R. H. Anholt (159214)

March 2012

<p>(A, B) Relationships between coefficients of genetic variance of inbred lines (CVL) and coefficie...

INVESTIGATION HIGHLIGHTED ARTICLE Additive, Epistatic, and Environmental Effects Through the Lens of Expression Variability QTL in a Twin Cohort

January 2016

ABSTRACT The expression of a gene can vary across individuals in the general population, as well as ...

Accounting for non-genetic factors improves the power of eQTL studies

Oliver Stegle
Anitha Kannan
Richard Durbin
John Winn

January 2008

Abstract. The recent availability of large scale data sets profiling sin-gle nucleotide polymorphism...

A Bayesian Framework to Account for Complex Non-Genetic Factors in Gene Expression Levels Greatly Increases Power in eQTL Studies

Stegle, O.
Parts, L.
Durbin, R.
Winn, J.

May 2010

Gene expression measurements are influenced by a wide range of factors, such as the state of the cel...

Diagnostics plots for processing pipeline.

Scott Wolf (9113613)
Diogo Melo (3289926)
Kristina M. Garske (11220178)
Luisa F. Pallares (7877681)
Amanda J. Lea (11790137)
Julien F. Ayroles (10580370)

July 2023

Gene expression variance has been linked to organismal function and fitness but remains a commonly n...

Discovery and overlap of expression QTLs and variance QTLs.

Abhishek K. Sarkar (6616010)
Po-Yuan Tung (6616013)
John D. Blischak (631103)
Jonathan E. Burnett (6616016)
Yang I. Li (6616019)
Matthew Stephens (3815)
Yoav Gilad (2481)

April 2019

(A) z-scores for expression QTL (eQTL) SNP-gene pairs discovered in pooled single cell RNA-seq data ...

Genome-Wide Expression Quantitative Trait Loci Analysis Using Mixed Models

Chaeyoung Lee

August 2018

Expression quantitative trait loci (eQTLs) are important for understanding the genetic basis of cell...

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

Vosa, U
Claringbould, A
Westra, HJ
Bonder, MJ
Deelen, P
Zeng, B
Kirsten, H
Saha, A
Kreuzhuber, R
Yazar, S
Brugge, H
Oelen, R
de Vries, DH
van der Wijst, MGP
Kasela, S
Pervjakova, N
Alves, I
Favve, MJ
Agbessi, M
Christiansen, MW
Jansen, R
Seppala, I
Tong, L
Teumer, A
Schramm, K
Hemani, G
Verlouw, J
Yaghootkar, H
Sonmez Flitman, R
Brown, A
Kukushkina, V
Kalnapenkis, A
Rueger, S
Porcu, E
Kronberg, J
Kettunen, J
Lee, B
Zhang, F
Qi, T
Hernandez, JA
Arindrarto, W
Beutner, F
Dmitrieva, J
Elansary, M
Fairfax, BP
Georges, M
Hewitt, AW
Heijmans, BT
Kahonen, M
Kim, Y
Knight, JC
Kovacs, P
Krohn, K
Li, S
Loeffler, M
Marigorta, UM
Mei, H
Momozawa, Y
Muller-Nurasyid, M
Nauck, M
Nivard, MG
Penninx, BWJH
Pritchard, JK
Raitakari, OT
Rotzschke, O
Slagboom, EP
Stehouwer, CDA
Stumvoll, M
Sullivan, P
't Hoen, PAC
Thiery, J
Tonjes, A
van Dongen, J
van Iterson, M
Veldink, JH
Volker, U
Warmerdam, R
Wijmenga, C
Swertz, M
Andiappan, A
Montgomery, GW
Ripatti, S
Perola, M
Kutalik, Z
Dermitzakis, E
Bergmann, S
Frayling, T
van Meurs, J
Prokisch, H
Ahsan, H
Pierce, BL
Lehtimaki, T
Boomsma, DI
Psaty, BM
Gharib, SA
Awadalla, P
Milani, L
Ouwehand, WH
Downes, K

January 2021

Trait-associated genetic variants affect complex phenotypes primarily via regulatory mechanisms on t...

Expression estimates using personalized HLA genotypes (x-axis) versus the reference transcriptome (y-axis) in the index.

Vitor R. C. Aguiar (6619328)
Jônatas César (5448176)
Olivier Delaneau (76754)
Emmanouil T. Dermitzakis (120302)
Diogo Meyer (231695)

April 2019

For each individual we identify the average divergence (proportion of mismatches) with respect to th...

Integrating genome-wide genetic variations and monocyte expression data reveals transregulated gene modules in humans. PLoS Genet doi:10.1371/journal

Maxime Rotival
Tanja Zeller
Seraya Maouche
Silke Szymczak
Arne Schillert
Carole Proust
Jessy Brocheton
Tiphaine Godefroy
Claire Perret
Marine Germain
Medea Eleftheriadis
Christoph R. Sinning
Renate B. Schnabel
Edith Lubos
Karl J
Heidi Rossmann
Augusto Rendon
Cardiogenics Consortium
Panos Deloukas
Christian Hengstenberg
Patrick Diemert
Gilles Montalescot
Willem H
Nilesh J. Samani
Heribert Schunkert
Re Tregouet
Andreas Ziegler
Alison H. Goodall
Laurence Tiret
Stefan Blankenberg

January 2011

One major expectation from the transcriptome in humans is to characterize the biological basis of as...

An approach for joint quantitative analysis of gene expression and regulatory QTLs.

Athma A. Pai (119315)
Jonathan K. Pritchard (113911)
Yoav Gilad (2481)

January 2015

<p>A goal of interindividual studies of regulatory mechanisms is to understand the extent to which v...

Estimates of additive and non-additive genetic components of transcript expression levels estimated using genetically orthogonal approaches in related and unrelated individuals.

Abstract

Extracted data

Estimates of additive and non-additive genetic components of transcript expression levels estimated using genetically orthogonal approaches in related and unrelated individuals.

Abstract

Extracted data

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