Effects of DFS in mice fed a high-fat diet (HFD mice).

<p>(A) Dose-dependent effect of DFS on change in body weight. (<b>B</b>) Time course of body weight changes in mice treated with DFS for 4 weeks and untreated mice. Black squares and solid lines = DFS 1.2 mg/g/day; white circles and solid lines = untreated controls. Effect of DFS treatment on change in body weight (<b>C</b>), average daily food intake (<b>D</b>), and serum levels of glucose (<b>E</b>), insulin (<b>F</b>), triglycerides (TGs) (<b>G</b>), and free fatty acids (FFAs) (<b>H</b>) in HFD mice over the entire 4-week treatment period. White bars = untreated controls; horizontal striped bars = DFS 0.12 mg/g/day; vertical striped bars = DFS 0.6 mg/g/day; black bars; DFS 1.2 mg/g/day. Values are the means and standard errors (n = 3–5 per group). *<i>P</i><0.05, **<i>P</i><0.01 <i>vs.</i> controls.