Effects of exendin (9–39) on weight and serum active GLP-1 levels in DFS-treated mice.

<p>(<b>A</b>) Body weights of saline-treated mice and mice treated with the GLP-1 receptor antagonist exendin (9–39) (Ex). Black squares and solid lines = saline-treated group; black triangles and dashed lines = Ex-treated group. (<b>B</b>) Comparison of changes in body weight at the end of the study. (<b>C</b>) Average daily food intake over the entire 5-day treatment period. Ex-treated and saline-treated mice were pair-fed. Black bars = saline-treated group; striped bars = Ex-treated group. (<b>D</b>) Serum levels of active GLP-1 in DFS-untreated controls, DFS-treated saline-treated (DFS) mice, and DFS-treated Ex-treated (DFS+Ex) mice. White bars = control; black bars = DFS; striped bars = DFS+Ex. Values are the means and standard errors (n = 3–4 per group). *<i>P</i><0.05 <i>vs.</i> the DFS group, <b>††</b><i>P</i><0.01 <i>vs.</i> the control group.