The major hemoglobinopathies: epidemiology, molecular pathology, and clinical phenotype.

<p>The human genome normally contains four copies of α-globin genes (in paired copies on chromosome 16: genotype αα/αα) and two copies of β-globin genes (on chromosome 11). Normal adult hemoglobin (HbAA) is a tetramer of two α-globin and two β-globin proteins.</p>a<p>Not technically a hemoglobinopathy but rather a normal hemoglobin variant of all newborns and infants.