TMZ resistant cells respond with cell cycle arrest to combined treatment.

<p><b>A</b> LN18 glioma cells were TMZ treated for three days consecutively with 100 µM, 200 µM and 500 µM and cell cycle analysis was performed afterwards. In comparison, CAP treatment without medium for 60 seconds was applied once to LN18 glioma cells, followed by TMZ treatment with 50 µM, 100 µM and 200 µM for three days consecutively. Cell cycle distribution was determined afterwards. <b>B</b> Analysis of the percentage of cells in the G2/M-phase after treatment with TMZ and combined treatment with CAP. P-value *** <0.001.