NetworKIN analysis of BIC VUSs affecting biologically characterized phosphorylation motifs in BRCA1 and BRCA2.

<p>In <b>bold</b> are BRCA1 mutations that directly mutate an experimentally identified phosphorylation site. ^aThe position and change at the amino acids specified by the missense variant is as reported in the BIC database. ^bThe nucleotide change conforms to the HGVS nomenclature. ^cSNP IDs correspond to the dbSNP database <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0062468#pone.0062468-Sherry1" target="_blank">[73]</a> SNP identifiers. ^dFrequency represents the number of times reported in the BIC database. ^eThe ten-residue long biologically uncharacterized kinase recognition motifs are shown. The biologically uncharacterized Serine (S), and threonine (T) residues shown to be phosphorylated by NetworKIN are underlined.