Human AAT monotherapy during pancreatic islet xenotransplantation.

<p>Rat pancreatic islets were grafted into the renal subcapsular space of hyperglycemic mice. Recipients were treated with saline (CT) or human AAT throughout the experiment. (<b>A</b>) Islet graft survival curve (<i>n</i> = 6/group). (<b>B</b>) Graft histology. Representative day-seven explanted grafts from CT and hATT-monotreated mice (<i>n</i> = 3/group). <i>Black arrows</i>, remains of rat pancreatic islets. (<b>C</b>) Mouse gene expression at graft site. Grafts were explanted at indicated times after transplantation. Mean ± SEM from <i>n</i> = 3 grafts/group; *p<0.05, **p<0.01, ***p<0.001. (<b>D</b>) Rat gene expression at graft site. Grafts were explanted at indicated times after transplantation. Mean ± SEM from <i>n</i> = 3 grafts/group; **p<0.01.