LPS, LBP and sCD14 levels in dengue virus infected patients.

<p>LPS: A: No significant differences in the 2009 WHO dengue case classification. B: Levels in patients with shock were significantly increased compared to patients without plasma leakage (P = 0,04). C: Cluster analysis: cluster C was significantly elevated compared to cluster A (P = 0,01), and B (P = 0,02). LBP: D: Levels were significantly elevated in all dengue patients compared to HC (WS− vs HC P = 0,009, WS+ vs HC P = 0,03, Severe vs HC P = 0,01). Levels in patients with severe dengue were significantly elevated compared to WS− dengue (P = 0,03). E: Levels were elevated in patients with shock (P = 0,008) and no plasma leakage (P = 0,008) compared to HC. Levels were also elevated in patients with shock compared to patients with plasma leakage (P = 0,03). F: In the cluster analysis levels in cluster C were significantly elevated compared to cluster A (P = 0,002) and B (P = 0,007). Moreover, cluster B was significantly elevated compared to cluster A (P<0,0001). sCD14: G: In the 2009 classification levels of sCD14 in DENV infected patients were significantly elevated compared to HC (WS−, WS+ and severe vs HC P<0,0001). Levels were significantly increased in WS+ compared to WS− patients (P = 0,04). H: In the plasma leakage/shock classification levels of sCD14 in DENV infected patients were significantly elevated compared to HC (No, PL and shock vs HC P<0,0001). I: In the cluster analysis cluster B (P<0,0001) and C (P = 0,002) were significantly elevated compared to cluster A. Abbreviations: HC : healthy control, WS−: non-severe dengue without warning signs. WS+: non-severe dengue with warning signs, No : No occurrence of plasma leakage, PL: occurrence of plasma leakage. Horizontal bars inside the boxplot indicate the median. The box indicates the interquartile range. Black asterisk = significantly different from all other groups. Underlined black asterisk = significant difference between two groups. The Mann-Whitney U test was used to compare the groups with each other.